Arsénio M. Fialho

Associate Professor with Habilitation

Research Activities

His research is focused on the study of bacterial proteins as novel anticancer agents. Studies aiming to elucidate the cellular and molecular effects of treating cancer cells with azurin, a cupredoxin produced by P. aeruginosa. His research interests also include the study of trimeric autotransporter adhesins as key virulence determinants in members of the Burkholderia cepacia complex, a group of bacteria that have emerged as opportunistic pathogens among individuals with cystic fibrosis.

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Selected Publications

Mil-Homens D., Leça M.I., Fernandes F., Pinto S.N., Fialho A.M. “Characterization of BCAM0224, a multifunctional trimeric autotransporter from the human pathogen Burkholderia cenocepacia” Journal of Bacteriology , 196(11):1968-79, 2014

Bernardes N., Ribeiro A. S., Abreu S., Vieira A.F., Carreto L., Santos M., Seruca R., Paredes J., Fialho A.M. “High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin” International Journal of Biochemistry & Cell Biology, 50:1-9, 2014

El-Kirat-Chatel S., Mil-Homens D., Beaussart A., Fialho A.M., Dufrêne Y.F. “Single-molecule atomic force microscopy unravels the binding mechanism of a Burkholderia cenocepacia trimeric autotransporter adhesin” Molecular Microbiology, 89(4):649-659, 2013

Bernardes N., Ribeiro A.S., Abreu S., Mota B., Matos R.G., Arraiano C.M., Seruca R., Paredes J., Fialho A.M. “The bacterial protein azurin impairs invasion and FAK/Src signaling in P-cadherin-overexpressing breast cancer cell models” PLoS One, 8 (7), e69023, 2013

Bernardes N., Chakrabarty A.M., Fialho A.M. “Engineering of bacterial strains and their products for cancer therapy” Applied Microbiology and Biotechnology 97(12):5189-5199, 2013

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